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Professor Alessio Ciulli

The Ciulli Group is broadly interested with understanding and exploiting the ligandability of protein-protein interactions (PPIs) and protein surfaces within complex biological systems using chemical and structural cell biology approaches. Current research efforts are directed towards targeting PPIs molecular recognition within protein families of biological and medical relevance within the Ubiquitin and Chromatin systems by developing small molecules that disrupt PPIs and that induce targeted protein degradation (PROTAC^®) as tools to probe biology and leads for drug discovery.

Ciulli Group Website

Recent papers from the Ciulli Group

Standley EA, Jamison TF. 2013. Simplifying Nickel(0) Catalysis: An Air-Stable Nickel Precatalyst for the Internally Selective Benzylation of Terminal Alkenes. J. Am. Chem. Soc.. 135(4):1585-1592. https://doi.org/10.1021/ja3116718

Testa A, Lucas X, Castro GV, Chan K, Wright JE, Runcie AC, Gadd MS, Harrison WTA, Ko E, Fletcher D, et al. 2018. 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation. J. Am. Chem. Soc.. 140(29):9299-9313. https://doi.org/10.1021/jacs.8b05807

Maniaci C, Hughes SJ, Testa A, Chen W, Lamont DJ, Rocha S, Alessi DR, Romeo R, Ciulli A. 2017. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 8(1): https://doi.org/10.1038/s41467-017-00954-1

Products available from the Ciulli Laboratory

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license

DISCIPLINES

Organic Synthetic Chemistry
Chemical Biology

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