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Merck

Obstruction of BRAF

Cancer gene therapy (2017-09-25)
J H Rothman, O Surriga, E de Stanchina, S D Vasudeva, G K Schwartz
PMID28937091
ABSTRACT

Peptide nucleic acid (PNA) oligomers are DNA mimics, which are capable of binding gene sequences 1000-fold more avidly than complementary native DNA by strand invasion and effectively obstruct transcription. Irreversibly obstructing the transcription or replication of a gene sequence, such as BRAF

MATERIALS
Product Number
Brand
Product Description
122564
Sigma-Aldrich
Mechlorethamine hydrochloride, 98%
233781
Sigma-Aldrich
Triisopropylsilane, 98%