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Surface charge switching nanoparticles for magnetic resonance imaging.

Surface charge switching nanoparticles for magnetic resonance imaging.

International journal of pharmaceutics (2014-05-27)

Dong Jin Lee, Young Taik Oh, Eun Seong Lee

ABSTRACT

In this study, polypeptide-based nanoparticles [constituted using poly(L-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in vitro cellular uptake and high accumulation in the acidic tumor site in vivo. Consequently, Fe3O4-loaded nanoparticles enabled high contrast magnetic resonance (MR) imaging of the tumor in vivo.

MATERIALS

Product Number

Brand

Product Description

Supelco

Acetic acid, analytical standard

Sigma-Aldrich

Triethylamine, for protein sequence analysis, ampule, ≥99.5% (GC)

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Acetic acid, for luminescence, BioUltra, ≥99.5% (GC)

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Triethylamine, BioUltra, ≥99.5% (GC)

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Triethylamine, for amino acid analysis, ≥99.5% (GC)

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Acetic acid, ≥99.5%, FCC, FG

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Acetic acid, natural, ≥99.5%, FG

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Lauric acid, ≥98%, FCC, FG

Supelco

N,N-Dimethylformamide, analytical standard

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Dodecylamine, ≥99%

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Dodecylamine, 98%

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Acetic acid-¹²C₂, 99.9 atom % ¹²C

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Diethyl ether

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Lauric acid, natural, ≥98%, FCC, FG

Supelco

Diethyl ether, analytical standard

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Triethylamine, ≥99.5%

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Triethylamine, ≥99.5%

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Triethylamine, puriss. p.a., ≥99.5% (GC)

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Diethyl ether, suitable for HPLC, ≥99.9%, inhibitor-free

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N,N-Dimethylformamide, suitable for HPLC, ≥99.9%

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Acetic acid solution, suitable for HPLC

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N,N-Dimethylformamide, for molecular biology, ≥99%

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Triethylamine, ≥99%

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Dodecylamine, puriss., ≥99.5% (GC)

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Bis(trichloromethyl) carbonate, purum, ≥99.0% (AT)

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N,N-Dimethylformamide, biotech. grade, ≥99.9%

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Diethyl ether, anhydrous, ACS reagent, ≥99.0%, contains BHT as inhibitor

Lauric acid, European Pharmacopoeia (EP) Reference Standard

Supelco

Triethylamine, analytical standard

Supelco

Dimethylformamide, Pharmaceutical Secondary Standard; Certified Reference Material