Skip to Content
Merck

An improved method for the preparation of [11C]verapamil.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2002-10-04)
T D Wegman, B Maas, P H Elsinga, W Vaalburg
PMID12361330
ABSTRACT

This paper describes an improved preparation of [11C]verapamil by reaction of [11C]methyl triflate with desmethylverapamil. The optimal reaction temperature, amount of precursor and reaction time were assessed. With this method [11C]verapamil can be prepared with a reproducible radiochemical yield of 66 +/- 4% (EOB, based on [11C]methyltriflate). Total synthesis time was 60 min. Radiochemical purity was >99% and specific activities varied between 5 and 30TBq/mmol.