- Highly enantioselective organocascade intermolecular iminium/enamine Michael addition on enals.
Highly enantioselective organocascade intermolecular iminium/enamine Michael addition on enals.
Chemical communications (Cambridge, England) (2011-05-24)
Adrien Quintard, Alexandre Alexakis
PMID21603716
ABSTRACT
An unprecedented intermolecular iminium/enamine Michael addition on enals has been developed by taking advantage of the high reactivity of vinyl sulfones. This powerful organocascade allows for the rapid construction of attractive synthons in high enantioselectivities (typically 99% ee).
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