- Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents.
Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents.
Bioorganic chemistry (2006-09-02)
Chamakura V N S Varaprasad, Kanda S Ramasamy, Jean-Luc Girardet, Esmir Gunic, Vicky Lai, Weidong Zhong, Haoyun An, Zhi Hong
PMID16945403
ABSTRACT
Several Toyocamycin (4) analogues were examined for their ability to inhibit HCV RNA in a replicon assay. Among the compounds examined 4-methylthio (18) and 5-carboxamide oxime derivatives (23 and 27) of Toyocamycin were found to have good activity and selectivity.
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