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HPA000864

Sigma-Aldrich

Anti-FKBP3 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-25 kDa FKBP antibody produced in rabbit, Anti-FK506-binding protein 3 antibody produced in rabbit, Anti-FKBP-25 antibody produced in rabbit, Anti-PPIase antibody produced in rabbit, Anti-Peptidyl-prolyl cis-trans isomerase antibody produced in rabbit, Anti-Rapamycin-selective 25 kDa immunophilin antibody produced in rabbit, Anti-Rotamase antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
HPA000864
NACRES:
NA.43

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human, rat, mouse

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500

immunogen sequence

LPKKDIIKFLQEHGSDSFLAEHKLLGNIKNVAKTANKDHLVTAYNHLFETKRFKGTESISKVSEQVKNVKLNEDKPKETKSEETLDEGPPKYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQDGT

UniProt accession no.

Q00688

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FKBP3(2287)

Immunogen

FK506-binding protein 3 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Biochem/physiol Actions

FK506-binding protein 3 is a protein encoded by the FKBP3 gene in humans and belongs to FK506-binding proteins. The protein is found both in the cytoplasm compartment and in the nuclear proteome. It is a nuclear protein associated with chromatin modifiers and transcription factors. It interacts with numerous ribosomal proteins, ribosomal processing factors and a small selection of chromatin modifiers. The protein interacts with the immature large ribosomal subunit in nuclear extract (but does not associate with mature ribosomes). It is likely to recruite preribosomes to chaperone one of the protein components of the ribosome large subunit. The protein may have role in ribosome biogenesis. It is associated to diverse components that are part of several different intracellular large-molecular mass entities. FKBP3 is a high-affinity rapamycin-binding immunophilin having nuclear translocation signals present in its PPIase domain.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST70427

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Geoff Gudavicius et al.
RNA (New York, N.Y.), 20(7), 1014-1022 (2014-05-21)
Peptidyl-proline isomerases of the FK506-binding protein (FKBP) family belong to a class of enzymes that catalyze the cis-trans isomerization of prolyl-peptide bonds in proteins. A handful of FKBPs are found in the nucleus, implying that the isomerization of proline in
Rapamycin-binding FKBP25 associates with diverse proteins that form large intracellular entities.
Galat A and Thai R
Biochemical and Biophysical Research Communications, 450(4), 1255-1260 (2014)

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