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933651

Sigma-Aldrich

Poly(caprolactone fumarate)

average Mn 5,000

Synonym(s):

PCLF, Polycaprolactone fumarate

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About This Item

Linear Formula:
C16H30O7(C20H30O9)n
UNSPSC Code:
12352207
NACRES:
NA.21

form

viscous liquid

Quality Level

100

mol wt

average Mn 5,000

color

clear, colorless

storage temp.

−20°C

General description

Poly(caprolactone fumarate) (PCLF) is a crosslinkable, biodegradable polymer consisting of poly(caprolactone) (PCL) and unsaturated fumarate repeating units. This derivative of PCL can be crosslinked to form a three-dimensional polymer network or scaffold. PCLF has been widely investigated for tissue engineering, 3D bioprinting, and drug delivery applications due to its biodegradability, biocompatibility and mechanical performance.

Application

  • Tissue engineering including bone and nerve regeneration
  • 3D bioprinting
  • Drug delivery
Poly(caprolactone fumarate) (PCLF) is a macromonomer consisting of poly(caprolactone) and fumarate repeating units. The bio-compatible poly(capralactone) units shows flexibility and fumarate repeat units provide cross linking ability without adding any toxic cross-linkers

Features and Benefits

  • Biocompatible
  • Crosslinkable via photopolymerization, radical polymerziation, thermal polymereization
  • Flexible polymer chain
  • Biodegradable via hydrolysis of the ster bonds in both PCL and fumarate segments

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Synthesis, Material Properties, and Biocompatibility of a Novel Self-Cross-Linkable Poly(caprolactone fumarate) as an Injectable Tissue Engineering Scaffold
Esmaiel J. et al.
Biomacromolecules, 6, 2503-2511 (2005)
Synthesis and manufacture of photocrosslinkable poly(caprolactone)-based three-dimensional scaffolds for tissue engineering applications
N. Castro et al.
Advances in Bioscience and Biotechnology, 2, 167-173 (2011)
M Brett Runge et al.
Acta biomaterialia, 8(1), 133-143 (2011-09-14)
Polycaprolactone fumarate (PCLF) is a cross-linkable derivative of polycaprolactone diol that has been shown to be an effective nerve conduit material that supports regeneration across segmental nerve defects and has warranted future clinical trials. Degradation of PCLF (PCLF(DEG)) releases toxic

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