WISP1
WNT1 inducible signaling pathway protein 1
Synonyms:
CCN4, WISP1c, WISP1i, WISP1tc
Species:
Human WISP1 (8840), Mouse Wisp1 (22402), Rat Wisp1 (65154), chicken WISP1 (420322), sheep WISP1 (101120418), dog WISP1 (482048), naked mole-rat Wisp1 (101722605), domestic guinea pig Wisp1 (100729064), cow WISP1 (539163), domestic cat WISP1 (101093993)
UniProtKB ID:
Gene ID:
- Human(8840) Summary: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]
- Mouse(22402) WNT1 inducible signaling pathway protein 1
- Rat(65154) WNT1 inducible signaling pathway protein 1
- chicken(420322) WNT1 inducible signaling pathway protein 1
- sheep(101120418) WNT1 inducible signaling pathway protein 1
- dog(482048) WNT1 inducible signaling pathway protein 1
- naked mole-rat(101722605) WNT1 inducible signaling pathway protein 1
- domestic guinea pig(100729064) WNT1 inducible signaling pathway protein 1
- cow(539163) WNT1 inducible signaling pathway protein 1
- domestic cat(101093993) WNT1 inducible signaling pathway protein 1
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ELISA
Product Number
Description
Species
Human WISP-1 / CCN4 ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Species
human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-WISP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Proteins
Product Number
Description
Species
WISP-1 human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Species
human
esiRNA
Product Number
Description
Species