- Total synthesis of alotaketal A.
Total synthesis of alotaketal A.
Organic letters (2012-10-26)
Mengyang Xuan, Ian Paterson, Stephen M Dalby
PMID23094646
ABSTRACT
The total synthesis of the cAMP signaling pathway activator (-)-alotaketal A is reported. A convergent approach to the unusual alotane sesterterpenoid skeleton was employed, exploiting a remarkable LiDBB-mediated coupling of an (R)-carvone-derived δ-lactone with an allyl bromide side chain, followed by spiroacetalization.
MATERIALS
Product Number
Brand
Product Description
Supelco
(+)-Carvone, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland