SML1741

TH1020

≥95% (HPLC)

• Synonym(s): 4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3′,2′,4,5]-thieno[3,2-d]pyrimidine, 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine
• Empirical Formula (Hill Notation): C₂₃H₁₅N₇S₂
• CAS Number: 1841460-82-9
• Molecular Weight: 453.54
• UNSPSC Code: 51111800
• PubChem Substance ID: 329826048
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 3 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: C1(C2=CC=NC=C2)=NN=C(SC3=NC=NC4=C3SC5=C4C=CC=N5)N1CC6=CC=CC=C6

Description

Application

TH1020 has been used to inhibit toll-like receptor 5 (TLR5) in porcine intestinal epithelial monolayer cells and mice.

Biochem/physiol Actions

TH1020 is a non-cytotoxic non-cytotoxic toll-like receptor 5 (TLR5)/flagellin complex inhibitor. TH1020 selectively prevents flagellin-induced TLR5 signaling without affecting ligands-induced activation of TLR2, TLR3, TLR4, TLR7 or TLR8.

TH1020 mediates the inhibition of tumor necrosis factor-α (TNF-α) based signaling, It disrupts tetrameric complex by binding the molecular interface between dimeric TLR5.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable