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Key Documents

SAB2500066

Sigma-Aldrich

Anti-Aminopeptidase A antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-APA, Anti-ENPEP, Anti-Glutamyl aminopeptidase A, Anti-HGNC:3355, Anti-gp160

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About This Item

MDL number:
MFCD03454728
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

Q07075

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ENPEP(2028)

General description

Aminopeptidase A (APA), also known as glutamyl aminopeptidase, is encoded by the gene mapped to human chromosome 4q25. APA is a type II membrane-bound protein. It is expressed in variety of organisms including, animal and plant tissues as well as in bacteria and fungi.

Immunogen

Peptide with sequence C-EQYQKTSLAQEKEK from the internal region of the protein sequence according to NP_001968.2.

Biochem/physiol Actions

Aminopeptidase A (APA) catalyzes the hydrolysis of an N-terminal peptide bond containing N-terminal glutamic acid or aspartic acid. It also plays a vital role in controlling blood pressure in the brain renin-angiotensin system. APA facilitates various processes such as protein maturation, activation, regulation, the degradation of bioactive peptides and in the determination of protein stability.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Enzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin IV.
Goto Y
The Journal of Biological Chemistry, 281(33), 23503-23513 (2006)
Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes.
Aoyagi T
The Journal of Antibiotics, 31(6), 636-638 (1978)
L Li et al.
Genomics, 43(3), 380-383 (1997-08-01)
The murine B-lymphocyte differentiation antigen BP-1/6C3 has been identified as glutamyl aminopeptidase (EAP), the gene symbol for which is ENPEP. Using genomic DNA encoding for human EAP as a probe, we identified the ENPEP gene location on human chromosome 4q25

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