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  • Cancer nanotechnology: enhanced therapeutic response using peptide-modified gold nanoparticles.

Cancer nanotechnology: enhanced therapeutic response using peptide-modified gold nanoparticles.

Journal of nanoscience and nanotechnology (2014-04-25)
Celina Yang, Mehrnoosh Neshatian, Monique van Prooijen
ABSTRACT

The applications of nanoparticles (NPs) for improved therapeutics are at the forefront of cancer nanotechnology. Gold nanoparticles (GNPs) have been extensively used due to their ability to act as both an anticancer drug carrier in chemotherapy and as a dose enhancer in radiotherapy. GNPs used in the studies were predominantly localized in the cell cytoplasm. However, the therapeutic response can be further enhanced if NPs can be effectively targeted into the nucleus. Here, we present an effective strategy for designing a GNP-peptide complex for nuclear targeting. Two peptides were conjugated onto a NP: One peptide enhanced the uptake while the other peptide enhanced the nuclear delivery. The nuclear targeted cells displayed a four-fold increase in the therapeutic response when treated with radiation as compared to untargeted ones. There was a modest increase in the DNA damage for radiated cells with nuclear targeted GNPs. This research will establish a more successful NP-based platform for combining more than one treatment modality, such as chemotherapy and radiotherapy, and creates a more aggressive approach in eradicating cancer.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Gold, beads, 1-6 mm, 99.999% trace metals basis
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Gold, rod, diam. 3.0 mm, 99.99% trace metals basis
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Gold, wire, diam. 0.1 mm, 99.99% trace metals basis
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Gold, foil, thickness 0.5 mm, 99.99% trace metals basis
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Gold, foil, thickness 0.25 mm, ≥99.9% trace metals basis
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Gold, foil, thickness 0.05 mm, 99.99% trace metals basis
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Gold, evaporation slug, diam. × L 0.6 cm × 0.6 cm, 99.99% trace metals basis
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Gold, wire, diam. 0.5 mm, 99.99% trace metals basis
Gold, insulated wire, 2m, conductor diameter 0.075mm, insulation thickness 0.012mm, PTFE (polytetrafluoroethylene) insulation, 99.99%
Gold, microfoil, disks, 10mm, thinness 0.05μm, specific density 101.3μg/cm2, permanent mylar 3.5μm support, 99.99+%
Gold, rod, 100mm, diameter 2.0mm, as drawn, 99.95%
Gold, microfoil, disks, 10mm, thinness 0.1μm, specific density 204.1μg/cm2, permanent mylar 3.5μm support, 99.99+%
Gold, tube, 50mm, outside diameter 8mm, inside diameter 7.8mm, wall thickness 0.1mm, as drawn, 99.95%
Gold, tube, 100mm, outside diameter 1.60mm, inside diameter 0.6mm, wall thickness 0.5mm, as drawn, 99.95%
Gold, tube, 200mm, outside diameter 2.0mm, inside diameter 1.8mm, wall thickness 0.1mm, as drawn, 99.95%
Gold, rod, 6mm, diameter 6.0mm, as drawn, 99.95%
Gold, rod, 10mm, diameter 6.0mm, as drawn, 99.95%
Gold, tube, 100mm, outside diameter 3.0mm, inside diameter 2.8mm, wall thickness 0.10mm, as drawn, 99.95%
Gold, tube, 100mm, outside diameter 10.0mm, inside diameter 9.7mm, wall thickness 0.15mm, as drawn, 99.95%
Gold, tube, 200mm, outside diameter 2.0mm, inside diameter 1.7mm, wall thickness 0.15mm, as drawn, 99.95%
Gold, insulated wire, 2m, conductor diameter 0.125mm, insulation thickness 0.014mm, polyester insulation, 99.99%
Gold, insulated wire, 0.5m, conductor diameter 0.075mm, insulation thickness 0.012mm, PTFE (polytetrafluoroethylene) insulation, 99.99%
Gold, insulated wire, 0.1m, conductor diameter 0.125mm, insulation thickness 0.016mm, PTFE (polytetrafluoroethylene) insulation, 99.99%
Gold, microfoil, disks, 10mm, thinness 0.5μm, specific density 966μg/cm2, permanent mylar 3.5μm support, 99.99+%
Gold, insulated wire, 1m, conductor diameter 0.05mm, insulation thickness 0.007mm, polyimide insulation, 99.99%