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Concise asymmetric total synthesis of obolactone.

The Journal of organic chemistry (2006-03-25)
Jiyong Zhang, Yang Li, Wenkuan Wang, Xuegong She, Xinfu Pan
ABSTRACT

The first efficient asymmetric synthesis of obolactone 1 has been accomplished in 11 steps and with a 15% overall yield in which Brown's enantioselective allylation reactions and ring-closing metathesis reaction are key steps.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Benzylideneacetone, ≥98%, FG
Sigma-Aldrich
4-Phenyl-3-buten-2-one, 99%
Sigma-Aldrich
trans-4-Phenyl-3-buten-2-one, ≥99%