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08062

Sigma-Aldrich

Protein G′ from Streptococcus sp.

recombinant, expressed in E. coli

Synonym(s):

IgG F(c)-Receptor

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About This Item

MDL number:
MFCD00132110
UNSPSC Code:
12352202
NACRES:
NA.26
Pricing and availability is not currently available.

biological source

bacterial (Streptococcus sp.)

Quality Level

100

recombinant

expressed in E. coli

form

lyophilized solid

mol wt

~30 kDa

capacity

~5 mg/mg, solid binding capacity (IgG)

storage temp.

−20°C

General description

Genetically engineered truncated protein G; retains affinity for IgG, but lacks albumin and Fab binding sites and membrane-binding regions.
Protein G, a cell wall protein,[1] is obtained from group G streptococci.[2] The extracellular part of this protein is made of two/three small domains or serum albumin binding (GA domains) and two/three immunoglobulin (IgG) binding domains (B domains).[1]

Application

Protein G′ from Streptococcus sp. has been used in in vitro actin labeling assay.[3]

Biochem/physiol Actions

Protein G can bind all the human and mouse IgG subclasses.[2] It can bind to both the fragment crystallizable (Fc) and antigen-binding fragment (Fab) components of the antibody.[1]

Physical form

lyophilized powder in a Tris-HCl buffer, pH 7.5

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM6248
BCCM6247
BCCL3355
BCCL0177
BCCG8269

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Essential Guides for Isolation/Purification of Immunoglobulins
Layer A, et al.
Encyclopedia of Separation Science, 4553-4559 (2000)
1405830
Nezlin R
The Immunoglobulins: Structure and Function null
Archana Kumari et al.
The EMBO journal, 39(14), e104006-e104006 (2020-06-23)
Cellular studies of filamentous actin (F-actin) processes commonly utilize fluorescent versions of toxins, peptides, and proteins that bind actin. While the choice of these markers has been largely based on availability and ease, there is a severe dearth of structural

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