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U5625

Sigma-Aldrich

Uridine 5′-diphosphoglucuronic acid ammonium salt

98-100%

Synonym(s):

UDP-GlcA, UDPGA, Uridine-diphosphate-glucuronic acid ammonium salt, Uridine[5′]diphospho[1]-α-D-glucopyranosuronic acid ammonium salt

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About This Item

Empirical Formula (Hill Notation):
C15H22N2O18P2 · xNH3
CAS Number:
Molecular Weight:
580.29 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51

biological source

Saccharomyces cerevisiae
enzyme from bovine liver (catalase)
enzyme from rabbit muscle (LDH)

Assay

98-100%

form

powder

storage temp.

−20°C

SMILES string

N.O[C@@H]1[C@@H](O)[C@H](O[C@@H]([C@H]1O)C(O)=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O

InChI

1S/C15H22N2O18P2.H3N/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25;/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26);1H3/t4-,6-,7+,8+,9-,10-,11+,12-,14-;/m1./s1

InChI key

WMWKTCPGFOEPBD-YGIWDPDDSA-N

General description

Uridine 5′-diphosphoglucuronic acid (UDPGA) is a cofactor, synthesized from UDPglucose and nicotinamide adenine dinucleotide (NAD+) intracellularly by the catalytic activity of UDPglucose dehydrogenase. The concentration of UDPGA in a number of liver preparations ranges from 0.3-0.5 mM.

Application

Uridine 5′-diphosphoglucuronic acid ammonium salt has been used in the initiation of UDP-glucuronosyl transferase (UDGPT) assay towards 14C-testosterone in the liver S9 protein. It is suitable for use in UDGPT assay.

Biochem/physiol Actions

Uridine 5′-diphosphoglucuronic acid (UDGPA) is the glucuronic acid donor for the conjugation of bilirubin in the endoplasmic recticulum.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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