U4885

UNC0638 hydrate

≥98% (HPLC)

• Synonym(s): 2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy) quinazolin-4-amine
• Empirical Formula (Hill Notation): C₃₀H₄₇N₅O₂ · xH₂O
• CAS Number: 1255517-77-1
• Molecular Weight: 509.73 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329827633
• UNSPSC Code: 12352200
• MDL number: MFCD17215972
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: protect from light

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: −20°C
• SMILES string: O.COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN4CCCC4)C5CCCCC5
• InChI: 1S/C30H47N5O2.H2O/c1-22(2)35-17-12-24(13-18-35)31-30-25-20-27(36-3)28(37-19-9-16-34-14-7-8-15-34)21-26(25)32-29(33-30)23-10-5-4-6-11-23;/h20-24H,4-19H2,1-3H3,(H,31,32,33);1H2
• InChI key: LLJGACAJGYXBTL-UHFFFAOYSA-N

Description

General description

UNC0638 enhances the E-cadherin expression in gemcitabine-resistant cell line (PANC-1-R).

Application

UNC0638 has been used to block G9a (a lysine methyltransferase) function in C2C12 cells[1]. UNC0638 has also been reported to decrease H3K9 dimethylation (H3K9me2) levels and inhibit cell death in hair cells[2].

UNC0638 hydrate has been used:

• in fractionation and isolation of human blood cells and cell nuclei
• in the analysis of human immunodeficiency virus (HIV) reactivation in latently infected cell line
• to determine the effect of G9a and its enzymatic activity on cisplatin resistance

Biochem/physiol Actions

Histone methyltransferase inhibitor (HMT); G9a/GLP selective methyltransferase chemical probe.

UNC0638 hydrate is a histone methyltransferase (HMT) inhibitor. UNC0638 shows selectivity for G9a (EHMT2) and GLP (EHMT1) methyltransferases, which catalyze the methylation of lysine 9 of histone 3 (H3K9) as well as other non-histone substrates. For full characterization details, please visit the UNC0638 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

UNC0638 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

Other Notes

UNC0638 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the UNC0638 probe summary on the Chemical Probes Portal website.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H300,H413
• pcodes: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral - Aquatic Chronic 4
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable