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15721

Sigma-Aldrich

Polydatin

≥95% (HPLC)

Synonym(s):

Piceid, Reservatrol-3-β-mono-D-glucoside, Resveratrol 3-O-β-D-glucopyranoside

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About This Item

Empirical Formula (Hill Notation):
C20H22O8
CAS Number:
65914-17-2
Molecular Weight:
390.38
Beilstein:
54837
UNSPSC Code:
12352201
PubChem Substance ID:
329750984
NACRES:
NA.25

Assay

≥95% (HPLC)

form

powder

optical activity

[α]1/D -66.0±2.0° in ethanol

composition

carbon, 60.5-62.5%

storage temp.

2-8°C

SMILES string

OCC1O[C@@H](Oc2cc(O)cc(\C=C\c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C20H22O8/c21-10-16-17(24)18(25)19(26)20(28-16)27-15-8-12(7-14(23)9-15)2-1-11-3-5-13(22)6-4-11/h1-9,16-26H,10H2/b2-1+/t16?,17-,18+,19-,20-/m1/s1

InChI key

HSTZMXCBWJGKHG-AEGFYQLOSA-N

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Application

Polydatin, a type of polyphenolic phytoalexin, has many physiological and pharmacological effects including anti-inflammatory and anti-oxidative activities. Polydatin is an effective candidate drug for the protection of photo-inflammation. Polydatin exhibits therapeutic potential for vascular dementia, most likely due to its anti-oxidant activity and the direct protection of neurons.

Biochem/physiol Actions

Stilbene found in medicinal herbs. Antioxidant, anti-inflammatory and neuroprotective.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jianxin Deng et al.
Journal of molecular and cellular cardiology, 53(5), 646-656 (2012-08-28)
Polydatin (PD), a resveratrol glucoside, has recently been suggested to have cardioprotective effects against heart diseases, including ischemia-reperfusion injury and pressure-overload induced ventricular remodeling. However, the mechanisms are poorly understood. This study aims to investigate the direct effects of PD
Jingming Zhang et al.
Molecular medicine reports, 6(4), 815-820 (2012-08-04)
The pathophysiology of non-alcoholic fatty liver disease remains incompletely elucidated, and available treatments are not entirely satisfactory. Polydatin, a stilbenoid compound derived from the rhizome of Polygonum cuspidatum, has been recognised to possess hepatoprotective and anti-inflammatory activities. The purpose of
Hyunsu Park et al.
Journal of agricultural and food chemistry, 60(33), 8183-8189 (2012-07-25)
Piceid is widely used in food, cosmetics, and pharmaceuticals because of its therapeutic benefits. However, the use of piceid as a drug is limited because of its low solubility. To increase solubility, we synthesized piceid glucosides using maltosyltransferase from Caldicellulosiruptor
Hong Zhang et al.
PloS one, 7(9), e46574-e46574 (2012-10-03)
Polydatin is one of main compounds in Polygonum cuspidatum, a plant with both medicinal and nutritional value. The possible hepatoprotective effects of polydatin on acute liver injury mice induced by carbon tetrachloride (CCl(4)) and the mechanisms involved were investigated. Intraperitoneal
Xingmin Wang et al.
Expert opinion on investigational drugs, 22(2), 169-179 (2012-12-18)
The aim of the study was find out whether neuronal mitochondrial injury does take place in severe shock and to explore effective therapy for severe shock. Rats were divided in the following group: sham, shock + normal saline (NS), shock
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