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119660

Sigma-Aldrich

Tris(2-chloroethyl) phosphate

97%

Synonym(s):

Phosphoric acid tris(2-chloroethyl) ester

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About This Item

Linear Formula:
(ClCH2CH2O)3P(O)
CAS Number:
115-96-8
Molecular Weight:
285.49
EC Number:
204-118-5
MDL number:
MFCD00000967
UNSPSC Code:
12352100
PubChem Substance ID:
24847295
NACRES:
NA.22

vapor pressure

<10 mmHg ( 25 °C)

Assay

97%

refractive index

n20/D 1.472 (lit.)

bp

192 °C/10 mmHg (lit.)

solubility

H2O: soluble 7.82 g/L

density

1.39 g/mL at 25 °C (lit.)

SMILES string

ClCCOP(=O)(OCCCl)OCCCl

InChI

1S/C6H12Cl3O4P/c7-1-4-11-14(10,12-5-2-8)13-6-3-9/h1-6H2

InChI key

HQUQLFOMPYWACS-UHFFFAOYSA-N

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General description

Tris(2-chloroethyl) phosphate is used as a flame retardant in plastics, especially inflexible foams used in automobiles and furniture and in rigid foams used for building insulation.

Application

Tris(2-chloroethyl) phosphate was used in dynamic air sampling of airborne organophosphate triesters using a solid-phase microextraction device.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H302,H351,H360

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

449.6 °F - closed cup

Flash Point(C)

232 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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H A Tilson et al.
Toxicology and applied pharmacology, 106(2), 254-269 (1990-11-01)
Adult female, Fischer-344 rats were exposed to 275 mg/kg of tris(2-chloroethyl)phosphate (TRCP) by gavage. TRCP produced consistent signs of convulsive activity within 60-90 min after dosing and extensive loss of CAT hippocampal pyramidal cells when examined 7 days after dosing.
H B Matthews et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 20(4), 477-485 (1993-05-01)
Previous short-term studies of tris(2-chloroethyl)phosphate (TRCP), a flame retardant used in industrial and consumer products, demonstrated that repeated administration of 350 mg TRCP/kg body wt by oral gavage resulted in necrosis of pyramidal neurons in the CA1 region of the
H B Matthews et al.
Toxicology and industrial health, 6(1), 1-15 (1990-01-01)
Tris(2-chloroethyl)phosphate (TRCP), a flame-retardant plasticizer used in plastics, polymeric foams and synthetic fibers, was studied as part of the National Toxicology Program's class study of phosphate flame-retardants. TRCP was administered at 0, 22, 44, 88, 175 and 350 mg/kg to
L T Burka et al.
Drug metabolism and disposition: the biological fate of chemicals, 19(2), 443-447 (1991-03-01)
Tris(2-chloroethyl) phosphate (TRCP), a flame retardant, produces a dose-, sex-, and species-dependent lesion in the hippocampal region of the brain following subchronic oral administration. This lesion is more common and more severe in female F344 rats than in male F344
T Umezu et al.
Toxicology and applied pharmacology, 148(1), 109-116 (1998-02-18)
The present study was conducted to clarify the acute effect of tris(2-chloroethyl)phosphate (TRCP), an organophosphate flame-retardant, on spontaneous ambulatory activity (AA) in male ICR mice and to examine the neurochemical mechanism of this effect. Single dose administration of 200 mg/kg
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