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Merck

Nucleic Acid Purification

The purity, quality, and quantity of your nucleic acid samples depends on reliable nucleic acid purification reagents and kits. We offer a variety of suitable kits for your nucleic acid sample needs, including gDNA, RNA, and plasmid purification, single spin purification, nucleic acid amplification, nucleic acid gel extraction, PCR clean-up, and more. Explore our comprehensive offering to maximize the reproducibility of your results and minimize the time spent on nucleic acid purification and related workflow needs.   

A box from Sigma-Aldrich, with the company’s logo visible on the packaging. In front of the box, there are six individual vials with white caps and clear bodies, arranged in two rows. Three vials are standing upright, and three are lying horizontally in front of an unopened product box which has red and white color scheme with additional labeling partially visible.

RNA Purification

RNA purification is a critical first step in many analyses due to the easy degradability of RNA. GenElute™ RNA purification kits enable purification of RNA from a variety of sources quickly and efficiently with minimal degradation, maximum purity, and high recovery and yield. GenElute™-E Single Spin RNA purification kits can be used to clean up RNA preps in a single spin for PCR and downstream applications.

Reaction Clean-Up

Cleanup of PCR reactions, restriction digests, sequencing reactions, and agarose and polyacrylamide gel extracts is essential for removing contaminants such as salts, enzymes, unincorporated dNTPs, primers, ethidium bromide, and other impurities that can interfere with downstream analysis. A selection of products for cleaning up DNA and RNA from enzymatic reactions or pre-purified samples is available for flexibility and convenience.

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gDNA Purification
gDNA Purification

High yield, high quality DNA extraction and purification kits tailored to a variety of common and challenging sample types including cell culture, mammalian tissue, blood, viruses, bacteria, plant tissue, soil, water, urine, stool, PCR reactions, and agarose gel extractions.

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Plasmid DNA Purification
Plasmid DNA Purification

Plasmid DNA purification kits offered in miniprep, midiprep, maxiprep, and gigaprep sizes for small to large scale purification of plasmid DNA for molecular cloning, transformation, and recombinant protein expression applications.

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