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Key Documents

P1742

Sigma-Aldrich

Prealbumin from human plasma

lyophilized powder

Synonym(s):

Thyroxine binding prealbumin, Transthyretin

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About This Item

CAS Number:
87090-18-4
MDL number:
MFCD00132069
UNSPSC Code:
12352202
NACRES:
NA.25

biological source

human plasma

Quality Level

200

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

technique(s)

immunoelectrophoresis: suitable
immunoprecipitation (IP): suitable

solubility

H2O: soluble 1 mg/mL

ε (extinction coefficient)

13.5 at 280 nm at 1%

UniProt accession no.

P02766

storage temp.

−20°C

Gene Information

human ... TTR(7276)

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General description

Human prealbumin is a product of chromosome 18. It is a serum protein, synthesized primarily in the liver. It is a tetrameric protein with a molecular weight of 55 kDa. Human prealbumin is composed of four identical non-covalently bound monomers of 127 amino acid residues arranged with tetrahedral symmetry.

Application

Human prealbumin was used to study reduced transthyretin expression in sera of lung cancer.
Prealbumin from human plasma has been used as a positive control in immunoprecipitation as a reference standard in quantitative rocket immunoelectrophoresis for quantification of cerebrospinal fluid.

Biochem/physiol Actions

Human prealbumin has been observed in carcinoid tumors.
Prealbumin levels are indictors of malnutrition and may be modulated during inflammation. It is regarded as potential marker of protein energy malnutrition (PEM) during chronic kidney failure supported dialysis. Low levels of prealbumin poses high risk to heart failure (HF).

Packaging

Package size based on protein content

Physical form

Lyophilized powder containing sodium phosphate and NaCl

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Prealbumin is as important as albumin in the nutritional assessment of hemodialysis patients
Chertow GM, et al.
Kidney International, 58(6), 2512-2517 (2000)
Takashi Ito et al.
Internal medicine (Tokyo, Japan), 45(20), 1173-1175 (2006-11-16)
Previously no functional study has been available for the mechanism of constipation in familial amyloid polyneuropathy (FAP). We performed a gut function test in a 78-year-old woman with transthyretin-type FAP who had severe constipation. The gut function test showed a
Distinct transthyretin oxidation isoform profile in spinal fluid from patients with Alzheimer?s disease and mild cognitive impairment
Poulsen K, et al.
Clinical Proteomics, 11(1), 12-12 (2014)
FAP World Transplant Register and domino/sequential register update.
G Herlenius et al.
Transplantation proceedings, 33(1-2), 1367-1367 (2001-03-27)
A combined biomarker pattern improves the discrimination of lung cancer
Liu L, et al.
Biomarkers, 16(1), 20-30 (2011)
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