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  • A new general access to either type of Securinega alkaloids: synthesis of securinine and (-)-allonorsecurinine.

A new general access to either type of Securinega alkaloids: synthesis of securinine and (-)-allonorsecurinine.

Organic letters (2004-05-21)
Ramon Alibés, Marta Ballbé, Félix Busqué, Pedro de March, Laia Elias, Marta Figueredo, Josep Font
ABSTRACT

The syntheses of securinine and (-)-allonorsecurinine have been achieved starting from easily available alpha-amino acid derivatives and using as key steps a RCM and a Heck reaction for the formation of rings D and C, respectively. [reaction: see text]

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Boc-L-prolinal, 97%
Sigma-Aldrich
Securinine, ≥98% (HPLC)