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  • A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment.

A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment.

Nanoscale (2015-07-01)
Dennis B Pacardo, Bhanu Neupane, S Michaela Rikard, Yue Lu, Ran Mo, Sumeet R Mishra, Joseph B Tracy, Gufeng Wang, Frances S Ligler, Zhen Gu
ABSTRACT

A multifunctional gold nanorod (AuNR) complex is described with potential utility for theranostic anticancer treatment. The AuNR was functionalized with cyclodextrin for encapsulation of doxorubicin, with folic acid for targeting, and with a photo-responsive dextran-azo compound for intracellular controlled drug release. The interaction of a AuNR complex with HeLa cells was facilitated via a folic acid targeting ligand as displayed in the dark-field images of cells. Enhanced anticancer efficacy was demonstrated through the synergistic combination of promoted drug release upon ultraviolet (UV) light irradiation and photothermal therapy upon infrared (IR) irradiation. This multifunctional AuNR-based system represents a novel theranostic strategy for spatiotemporal delivery of anticancer therapeutics.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Dimethyl sulfoxide-d6, "100%", 99.96 atom % D, contains 0.03 % (v/v) TMS
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N,N-Dimethylformamide, ACS reagent, ≥99.8%
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L-Ascorbic acid, 99%
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Dimethyl sulfoxide-d6, 99.5 atom % D
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CDI, ≥97.0% (T)
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Trypan Blue, ≥80% (HPLC), Dye content 60 %
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L-Ascorbic acid, puriss. p.a., ≥99.0% (RT)
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11-Mercaptoundecanoic acid, 95%
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Silver nitrate, 99.9999% trace metals basis
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CDI, reagent grade
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L-Ascorbic acid, ACS reagent, ≥99%
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Dimethyl sulfoxide-d6, 99.9 atom % D, contains 1 % (v/v) TMS
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Dimethyl sulfoxide-d6, "100%", 99.96 atom % D
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Dimethyl sulfoxide-d6, anhydrous, 99.9 atom % D
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Sodium borohydride solution, 2.0 M in triethylene glycol dimethyl ether
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Dimethyl sulfoxide-d6, 99.9 atom % D, contains 0.03 % (v/v) TMS
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N,N-Dimethylformamide, anhydrous, 99.8%
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L-Ascorbic acid, reagent grade
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L-Ascorbic acid, powder, suitable for cell culture, γ-irradiated
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L-Ascorbic acid, reagent grade, crystalline
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L-Ascorbic acid, BioXtra, ≥99.0%, crystalline
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Dimethyl sulfoxide-d6, "Special HOH", ≥99.9 atom % D
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Silver nitrate, BioXtra, >99% (titration)
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Silver nitrate, BioReagent, suitable for plant cell culture, >99% (titration)
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