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M3655

Sigma-Aldrich

D-Mannose 6-phosphate sodium salt

≥98% (HPLC)

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About This Item

Linear Formula:
C6H12O9PNa
CAS Number:
70442-25-0
Molecular Weight:
282.12
MDL number:
MFCD00135859
UNSPSC Code:
12352201
PubChem Substance ID:
24896863
NACRES:
NA.25

biological source

synthetic (inorganic)

Assay

≥98% (HPLC)

form

powder

technique(s)

HPLC: suitable

impurities

<12% water (Karl Fischer)

color

white

solubility

water: 50 mg/mL, clear to cloudy, colorless

cation traces

Na: 7.3-9.0% (anhydrous)

storage temp.

2-8°C

SMILES string

[Na].OC(COP(O)(O)=O)C(O)C(O)C(O)C=O

InChI

1S/C6H13O9P.Na.H/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14;;/h1,3-6,8-11H,2H2,(H2,12,13,14);;

InChI key

RUFPTDNHMAGVMV-UHFFFAOYSA-N

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General description

Mannose is a monosaccharide.

Application

Mannose has been used in a study to assess in vivo targeting of alveolar macrophages. It has also been used in a study to investigate genetic engineering of the phosphocarrier protein NPr.

Biochem/physiol Actions

Mannose-6-Pis a molecule bound by lectin in the immune system. It is converted to fructose 6-phosphate by mannose phosphate isomerase and is a key targeting signal for acid hydrolase precursor proteins that are transported to lysosomes.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Yossef Lopez-de Los Santos et al.
The Journal of biological chemistry, 287(35), 29931-29939 (2012-07-07)
The Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system (PTS) in prokaryotes mediates the uptake and phosphorylation of its numerous substrates through a phosphoryl transfer chain where a phosphoryl transfer protein, HPr, transfers its phosphoryl group to any of several sugar-specific Enzyme IIA
Maria Francisca Coutinho et al.
Molecular genetics and metabolism, 105(4), 542-550 (2012-01-24)
Lysosomal hydrolases are synthesized in the rough endoplasmic reticulum and specifically transported through the Golgi apparatus to the trans-Golgi network, from which transport vesicles bud to deliver them to the endosomal/lysosomal compartment. The explanation of how are the lysosomal enzymes
Ningning Yang et al.
Journal of controlled release : official journal of the Controlled Release Society, 155(2), 326-330 (2011-07-19)
Triplex-forming oligonucleotides (TFOs) represent an antigene approach for gene regulation through direct interaction with genomic DNA. While this strategy holds great promise owing to the fact that only two alleles need silencing to impact gene regulation, delivering TFOs to target
Katrin Marschner et al.
Science (New York, N.Y.), 333(6038), 87-90 (2011-07-02)
Mucolipidosis II is a severe lysosomal storage disorder caused by defects in the α and β subunits of the hexameric N-acetylglucosamine-1-phosphotransferase complex essential for the formation of the mannose 6-phosphate targeting signal on lysosomal enzymes. Cleavage of the membrane-bound α/β-subunit
Petra Tiels et al.
Nature biotechnology, 30(12), 1225-1231 (2012-11-20)
Lysosomal storage diseases are treated with human lysosomal enzymes produced in mammalian cells. Such enzyme therapeutics contain relatively low levels of mannose-6-phosphate, which is required to target them to the lysosomes of patient cells. Here we describe a method for
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