Skip to Content
Merck
All Photos(2)

Key Documents

View All Documentation

D1068

Sigma-Aldrich

DCB

≥98% (HPLC), solid

Synonym(s):

3,3′-Dichlorobenzaldazine, NSC 67224

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C14H10Cl2N2
CAS Number:
6971-97-7
Molecular Weight:
277.15
MDL number:
MFCD00556081
UNSPSC Code:
12352200
PubChem Substance ID:
24724458
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

storage condition

desiccated
under inert gas

color

yellow

solubility

DMSO: ~6.8 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

Clc1cccc(\C=N\N=C\c2cccc(Cl)c2)c1

InChI

1S/C14H10Cl2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+

InChI key

XMOVWXSCYLINBJ-BEQMOXJMSA-N

Biochem/physiol Actions

3,3′-dichlorobenzaldazine (DCB) serves as an allosteric ligand with neutral cooperativity. It helps to block the positive allosteric regulation of mGluRs (metabotropic glutamate receptor subtype 5 (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) and the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB).
Neutral allosteric modulator of the metabotropic glutamate receptor mGluR5.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Pierre Josse et al.
Molecules (Basel, Switzerland), 23(4) (2018-04-21)
The synthesis and preliminary evaluation as donor material for organic photovoltaics of the poly(diketopyrrolopyrrole-spirobifluorene) (PDPPSBF) is reported herein. Prepared via homogeneous and heterogeneous direct (hetero)arylation polymerization (DHAP), through the use of different catalytic systems, conjugated polymers with comparable molecular weights
Anna Baranska et al.
The Journal of experimental medicine, 215(4), 1115-1133 (2018-03-08)
Here we describe a new mouse model that exploits the pattern of expression of the high-affinity IgG receptor (CD64) and allows diphtheria toxin (DT)-mediated ablation of tissue-resident macrophages and monocyte-derived cells. We found that the myeloid cells of the ear
Boya Zhang et al.
Nanomaterials (Basel, Switzerland), 9(9) (2019-09-22)
The electrical and optical properties of the hole transport layer (HTL) are critical for organic and halide perovskite solar cell (OSC and PSC, respectively) performance. In this work, we studied the effect of Mg doping on CuCrO2 (CCO) nanoparticles and
Xiaohui Liu et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 4(8), 1700053-1700053 (2017-08-31)
Landmark power conversion efficiency (PCE) over 10% has been accomplished in the past year for single-junction organic solar cell (OSCs), suggesting a promising potential application of this technology. However, most of the high efficient OSCs are based on inverted configuration.
Wesley Yeung et al.
PloS one, 15(7), e0235166-e0235166 (2020-07-02)
Monitoring of blood pressure is an important part of management of dengue illness. Large scale studies of temporal trend of blood pressure in adult dengue are lacking. In this study, we examined the differences in time trend of systolic (SBP)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service