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Chlorpromazine hydrochloride

Name: Chlorpromazine hydrochloride
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₉ClN₂S · HCl

CAS Number:

69-09-0

Molecular Weight:

355.33

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329774913

MDL number:

MFCD00012654

Beilstein/REAXYS Number:

3779989

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Properties

grade

pharmaceutical primary standard

API family

chlorpromazine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

InChI key

FBSMERQALIEGJT-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

Biochem/physiol Actions

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist, H₁ histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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This Item	BP856	C0982	1125006
C1900000 Chlorpromazine hydrochloride	BP856 Chlorpromazine hydrochloride	Sigma-Aldrich C0982 Chlorpromazine hydrochloride	USP 1125006 Chlorpromazine hydrochloride
manufacturer/tradename EDQM	manufacturer/tradename BP	manufacturer/tradename -	manufacturer/tradename USP
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade -	grade pharmaceutical primary standard
format neat	format neat	format -	format neat
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
Gene Information human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)	Gene Information human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)	Gene Information human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)	Gene Information human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)
API family chlorpromazine	API family chlorpromazine	API family -	API family chlorpromazine

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Explore all of our products under Chlorpromazine hydrochloride

pictograms

GHS06

signalword

Danger

hcodes

H301,H330

pcodes

P260 - P264 - P270 - P271 - P284 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice.

Cristiane Flora Villarreal et al.

Pharmacology, biochemistry, and behavior, 103(3), 678-683 (2012-11-28)

In recent years, evidence that sensitization of primary afferent nociceptors is an important event associated with chronic pain has been accumulating. The present study aimed to evaluate the participation of the prostaglandin and sympathetic components in the long-lasting sensitization of

In vitro biokinetics of chlorpromazine and the influence of different dose metrics on effect concentrations for cytotoxicity in Balb/c 3T3, Caco-2 and HepaRG cell cultures.

Jessica J W Broeders et al.

Toxicology in vitro : an international journal published in association with BIBRA, 27(3), 1057-1064 (2013-02-05)

The extrapolation of in vitro to in vivo toxicity data is a challenge. Differences in sensitivity between cell systems may be due to intrinsic properties of the cell but also because of differences in exposure. In this study, the cytotoxicity

Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.

Sébastien Anthérieu et al.

Hepatology (Baltimore, Md.), 57(4), 1518-1529 (2012-11-24)

Drugs induce cholestasis by diverse and still poorly understood mechanisms in humans. Early hepatic effects of chlorpromazine (CPZ), a neuroleptic drug known for years to induce intrahepatic cholestasis, were investigated using the differentiated human hepatoma HepaRG cells. Generation of reactive

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Global Trade Item Number

SKU	GTIN
C1900000	04061833468296

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