AB9906
Anti-QKI-6 Antibody
serum, Chemicon®
Synonym(s):
Quaking Protein
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, rat, human
manufacturer/tradename
Chemicon®
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... QKI(9444)
Related Categories
General description
QKI is an RNA-binding protein that plays a central role in myelinization. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. It is regulated by alternative splicing.
Specificity
QKI-6 (Quaking Protein). The antibody recognizes the ~38 kDa protein.
Immunogen
Synthetic peptide from mouse QKI-6.
Application
Anti-QKI-6 Antibody detects level of QKI-6 & has been published & validated for use in IP & WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
RNA Binding Protein (RBP)
Developmental Neuroscience
RNA Binding Protein (RBP)
Physical form
Liquid.
Serum
Storage and Stability
Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
Analysis Note
Control
Positive Control: Glial cells, astrocytes and oligodendrocytes.
Positive Control: Glial cells, astrocytes and oligodendrocytes.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Zhengyi Zhang et al.
Nature communications, 10(1), 4397-4397 (2019-09-29)
Strand-selection is the final step of microRNA biogenesis in which functional mature miRNAs are generated from one or both arms of precursor. The preference of strand-selection is diverse during development and tissue formation, however, its pathological effect is still unknown.
Zhejia Zhang et al.
Oncology letters, 15(4), 5841-5848 (2018-03-21)
Thyroid cancer is the most frequently occurring type of endocrine tumor, with a rapidly increasing incidence rate. MicroRNA (miR)-574-5p is a candidate oncogene in various types of cancer. The present study identified that miR-574-5p affected the cell cycle distribution and
Kristina Sakers et al.
Nature communications, 12(1), 1537-1537 (2021-03-23)
Quaking RNA binding protein (QKI) is essential for oligodendrocyte development as myelination requires myelin basic protein mRNA regulation and localization by the cytoplasmic isoforms (e.g., QKI-6). QKI-6 is also highly expressed in astrocytes, which were recently demonstrated to have regulated
Seula Shin et al.
Nature communications, 12(1), 3005-3005 (2021-05-23)
Defective cholesterol biosynthesis in eye lens cells is often associated with cataracts; however, how genes involved in cholesterol biosynthesis are regulated in lens cells remains unclear. Here, we show that Quaking (Qki) is required for the transcriptional activation of genes
Xinyun Chen et al.
Nature communications, 12(1), 89-89 (2021-01-06)
The RNA-binding protein QKI belongs to the hnRNP K-homology domain protein family, a well-known regulator of pre-mRNA alternative splicing and is associated with several neurodevelopmental disorders. Qki is found highly expressed in developing and adult hearts. By employing the human
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