Skip to Content
Merck
All Photos(1)

Documents

910457

Sigma-Aldrich

Poly(2-(diisopropylamino)ethyl methacrylate)

average Mn 10,000

Synonym(s):

Hydrophilic, PDPA, pH sensitive, pH-responsive

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
(C12H23NO2)n
UNSPSC Code:
12162002
NACRES:
NA.23

form

powder or solid

mol wt

average Mn 10,000 (by NMR)
average Mn 10,000

color

white to faint yellow

PDI

≤1.3 (by GPC)

storage temp.

2-8°C

Application

Poly(2-(diisopropylamino)ethyl methacrylate) is a pH-responsvie polymer. pH-Responsive polymers are a group of stimuli-responsive polymers that can respond to solution pH by undergoing structural and property changes such as surface activity, chain conformation, solubility, and configuration. The term “pH-responsive polymers” is commonly used to describe polymers having ionisable acidic or basic residues whose ionization depends on solution pH. The physical properties of the polymer, such as its chain conformation, configuration, and solubility, can be tailored by manipulating the pH or ionic strength. These unique properties of pH responsive polymer systems consequently make them very useful in various applications such as drug delivery, gene delivery, sensors, surfaces, membranes, and chromatography.
pH-sensitive polymer systems combined with nanotechnology could be utilized as an alternative strategy to traditional targeting systems to overcome major problems in current chemotherapy represented by non-specific tissue distribution of the drugs, tumor heterogeneity, and multidrug resistance (MDR) against anticancer drugs.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

pH-Responsive polymers
Kocak G, et al.
Polym. Chem., 8, 144-176 (2017)
Jing Xie et al.
Macromolecular rapid communications, 38(23), 1499-1499 (2017-10-05)
Since diabetes mellitus has become one of the most serious threats to human health, researchers have been designing new drugs and developing new technologies to control the blood glucose level (BGL) while improving patient compliance. In addition to the traditional
Hong-ming Ding et al.
Scientific reports, 3, 2804-2804 (2013-10-01)
The major challenge in cancer therapy is to efficiently translocate drug molecules into cancer tumors without doing any damage to healthy tissues. Since there exist pH gradients between tumor and normal tissues, pH-sensitive materials may have great potential to overcome
Themis R Kyriakides et al.
Journal of controlled release : official journal of the Controlled Release Society, 78(1-3), 295-303 (2002-01-05)
Cytosolic delivery from endosomes is critical for those drugs that are susceptible to attack by lysosomal enzymes, such as DNA, RNA, oligonucleotides, proteins and peptides. Therefore, we have designed pH-sensitive, membrane-disruptive polymers to enhance the release of drugs from the
Girish Kumar Tripathi et al.
Current drug delivery, 8(6), 667-677 (2012-02-09)
Helicobacter pylori reside in the gastric mucus layer and at the mucus-epithelial cell interface wherein access of antimicrobial drug to the infection site is restricted both from the stomach and from the gastric blood supply. The aim of the present
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service