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  • Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure.

Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure.

Basic research in cardiology (2017-02-27)
Justin R Kingery, Tariq Hamid, Robert K Lewis, Mohamed Ameen Ismahil, Shyam S Bansal, Gregg Rokosh, Tim M Townes, Suzanne T Ildstad, Steven P Jones, Sumanth D Prabhu
PMID28238121
ABSTRACT

In the failing heart, iNOS is expressed by both macrophages and cardiomyocytes. We hypothesized that inflammatory cell-localized iNOS exacerbates left ventricular (LV) remodeling. Wild-type (WT) C57BL/6 mice underwent total body irradiation and reconstitution with bone marrow from iNOS