- Mutagenicity of 4-nitrodiphenyl ether and its metabolites.
Mutagenicity of 4-nitrodiphenyl ether and its metabolites.
Toxicology letters (1986-11-01)
R L Gupta, D K Dey, T R Juneja
PMID3538501
ABSTRACT
The mutagenic potential of 4-nitrodiphenyl ether (NDE) an intermediate of herbicides and an anthelmintic drug, and its reduced products (-NO, -NHOH) were investigated in the Ames test. All the three compounds were potent direct-acting base-pair and frameshift mutagens with activity order -NHOH greater than -NO greater than -NO2. The -NHOH compound has been considered to be the penultimate/ultimate mutagen.