- Aldol reactions mediated by a tetrahedral boronate.
Aldol reactions mediated by a tetrahedral boronate.
Chemical communications (Cambridge, England) (2012-11-30)
Tobias Müller, Kristina Djanashvili, Isabel W C E Arends, Joop A Peters, Ulf Hanefeld
PMID23191985
ABSTRACT
The base is a key factor in aldol reactions in organic media, determining the selectivity. Here, we describe a tetrahedral phenylboronate salt as a mild non-nucleophilic base that is able to catalyse the aldol reaction and significantly decrease the formation of undesired elimination products.