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Merck

RUNX2

runt-related transcription factor 2

Synonyms:
AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA
Species:
UniProtKB ID:
Gene ID:
  • Human(860) Summary: This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008]
  • Mouse(12393) runt related transcription factor 2
  • Rat(367218) runt-related transcription factor 2
  • Goat(100861217) runt-related transcription factor 2
  • domestic guinea pig(100734175) runt-related transcription factor 2
  • cow(536911) runt-related transcription factor 2
  • chicken(373919) runt-related transcription factor 2
  • Domestic Rabbit(100008943) runt-related transcription factor 2
  • Horse(100033890) runt-related transcription factor 2
  • domestic cat(101089612) runt-related transcription factor 2
  • sheep(101115489) runt-related transcription factor 2
  • dog(474923) runt-related transcription factor 2
  • dog(449531) runt-related transcription factor 2
  • naked mole-rat(101724767) runt-related transcription factor 2

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-RUNX2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Monoclonal Anti-RUNX2 antibody produced in mouse, clone 1D8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
ANTI-RUNX2 antibody produced in mouse, clone 1D2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Monoclonal Anti-RUNX2 antibody produced in mouse, clone 4D5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Monoclonal Anti-RUNX2 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0235, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human RUNX2,
Species
human