- Impact of heart magnetic resonance imaging on chelation choices, compliance with treatment and risk of heart disease in patients with thalassaemia major.
Impact of heart magnetic resonance imaging on chelation choices, compliance with treatment and risk of heart disease in patients with thalassaemia major.
British journal of haematology (2013-09-17)
Raffaella Origa, Fabrice Danjou, Stefano Cossa, Gildo Matta, Patrizio Bina, Carlo Dessì, Elisabetta Defraia, Maria L Foschini, Giovanbattista Leoni, Maddalena Morittu, Renzo Galanello
PMID24033185
ABSTRACT
This study aimed to verify the impact of heart magnetic resonance imaging on chelation choices and patient compliance in a single-institution cohort as well as its predictive value for heart failure and arrhythmias. Abnormal cardiac T2* values determined changes in treatment in most subjects. Heart T2* was confirmed to be highly predictive over 1 year for heart failure and arrhythmias. The choice of chelation regimens known to remove heart iron efficiently was not sufficient by itself to influence the risk. Compliance with treatment had a more remarkable role.
MATERIALS