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Merck

In vitro evaluation of apoptosis with 99mTc-glucoheptonate.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2011-04-05)
Gamze Kocagozoglu, Fatma Yurt Lambrecht, Cumhur Gunduz, Musteyde Yucebaş, Elif Bayrak Tabar, Aykut Ozgur, Tugce Balci
PMID21459007
ABSTRACT

Radiopharmaceuticals are useful to evaluate effectiveness of cancer treatments as well as diagnosis of diseases. (99m)Tc-Glucoheptonate has high sensitivity for imaging lung cancer tissues. In this study, the potential use of (99m)Tc-glucoheptonate for monitoring apoptosis related to chemotherapeutic agents is investigated in vitro using A549 lung cancer cell line. A decrease in (99m)Tc-glucoheptonate uptake ratio was observed depending on the level of apoptosis. (99m)Tc-glucoheptonate is found to be useful for the detection of apoptosis following treatment in A549 lung tumor cells.