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  • Influence of N,N'-diacetyl-L-cystine on D-galactosamine/lipopolysaccharide induced immunological liver failure in mice.

Influence of N,N'-diacetyl-L-cystine on D-galactosamine/lipopolysaccharide induced immunological liver failure in mice.

Yao xue xue bao = Acta pharmaceutica Sinica (2005-02-11)
Pei Wang, Xing-chang Ren, Jin Yu, Yi Lin, Xi-ming Wu
ABSTRACT

To study the therapeutic effects of N,N'-diacetyl-L-cystine (DiNAC) on immunological liver failure. Serum ALT, AST and T cell subsets in peripheral blood of the experimental animals during the trial period were analyzed by an automatic serum analyzer and a flow cytometer, respectively. The sectioned liver specimens were examined under a light microscope. And 24 h after the injection of Gal/LPS, the survival rate of rats was calculated. DiNAC (50, 200, 800 mg x kg(-1), i.p.) suppressed the elevation of serum levels of ALT and AST, markedly enhanced proliferation and differentiation of T cell subsets (CD4+, CD8+ and Th1, Th2), and improved all the histopathological features. In mice of fulminant hepatic failure (FHF), the survival time significantly prolonged and the survival rate increased 24 h after i.p. DiNAC. These effects were obviously dose-dependent. DiNAC on mice with FHF has an inhibitory action which is related to immune mechanism.

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Acetylcysteine impurity C, European Pharmacopoeia (EP) Reference Standard
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