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  • A novel synthesis of (E)-3-methylthio-3-substituted arylamino-2-cyanoacrylates under microwave irradiation.

A novel synthesis of (E)-3-methylthio-3-substituted arylamino-2-cyanoacrylates under microwave irradiation.

Molecules (Basel, Switzerland) (2007-11-17)
Guiping Ouyang, Baoan Song, Huiping Zhang, Song Yang, Linhong Jin, Qianzhu Li, Deyu Hu
ABSTRACT

A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% ~ 93.5%) in 30 minutes at 50 degrees C under microwave irradiation. This method is very simple and the reaction conditions are mild, environmentally friendly and more importantly, quick. In the 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, some of the title compounds were found to possess good antiproliferation activity towards PC3 cells.

MATERIALS
Product Number
Brand
Product Description

Leflunomide impurity A, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
4-(Trifluoromethyl)aniline, 99%