- Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2.
Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2.
Bioorganic & medicinal chemistry letters (2010-04-02)
K A Nolan, M P Humphries, R A Bryce, I J Stratford
PMID20356739
ABSTRACT
The purpose of the work was to identify novel inhibitors of the enzyme NQO2. Using computational molecular modelling, a QSAR (R(2)=0.88) was established, relating inhibitory potency with calculated binding affinity. From this, the imidazoacridin-6-one, NSC660841, was identified as the most potent inhibitor of NQO2 yet reported (IC(50)=6 nM).