SML1225

Indisulam

≥98% (HPLC)

• Synonym(s): N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide, N₁-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
• Empirical Formula (Hill Notation): C₁₄H₁₂ClN₃O₄S₂
• CAS Number: 165668-41-7
• Molecular Weight: 385.85
• MDL number: MFCD00945325
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825730
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to pink
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: ClC1=CNC2=C1C=CC=C2NS(C3=CC=C(S(=O)(N)=O)C=C3)(=O)=O
• InChI: 1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
• InChI key: SETFNECMODOHTO-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition.

Indisulam is synthetic sulfonamide compound. In vitro and in vivo studies point out that indisulam prevents retinoblastoma protein phosphorylation. Also, it inhibits cyclins A and B1 activity. Indisulam is known to promote apoptosis. Indisulam is a potent inhibitor of cellular dehydrogenases and thus, is likely to interfere with metabolic pathways such as malate-aspartate shuttle, glycolysis and gluconeogenesis.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable