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Key Documents

SAB4300254

Sigma-Aldrich

Anti-phospho-NTRK1 (pSer791) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-DKFZp781I14186 antibody produced in rabbit, Anti-MTC antibody produced in rabbit, Anti-TRK antibody produced in rabbit, Anti-TRK1 antibody produced in rabbit, Anti-neurotrophic tyrosine kinase, receptor, type 1 antibody produced in rabbit

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About This Item

MDL number:
MFCD00239748
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~140 kDa

species reactivity

mouse, human, rat

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:100-1:200

isotype

IgG

immunogen sequence

(P-V-YP-L-D)

NCBI accession no.

NP_001007793.1

UniProt accession no.

P04629

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer791)

Gene Information

human ... NTRK1(4914)

Immunogen

Peptide sequence around phosphorylation site of tyrosine791 (P-V-Y(p)-L-D), according to the protein NTRK1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Deidiane Elisa Ribeiro et al.
Progress in neuro-psychopharmacology & biological psychiatry, 93, 232-239 (2019-04-17)
Nitric oxide (NO) triggers escape reactions in the dorsal periaqueductal gray matter (dPAG), a core structure mediating panic-associated response, and decreases the release of BDNF in vitro. BDNF mediates the panicolytic effect induced by antidepressant drugs and produces these effects

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