Surface protein CD20 serves as the critical target of immunotherapy in various B-cell malignancies for decades, however its biological function and regulation remain largely elusive. Better understanding of CD20 function may help to design improved rational therapies to prevent development
Bruton's tyrosine kinase (Btk) is critical for B-cell maturation and activation. Btk loss-of-function mutations cause human X-linked agammaglobulinemia (XLA). In contrast, Btk signaling sustains growth of several B-cell neoplasms which may be treated with tyrosine kinase inhibitors (TKIs). Here, we
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 67(10), 847-861 (2018-08-16)
To investigate the amelioration effects of quetiapine on rheumatoid arthritis with RAW 264.7 macrophage and collagen-induced arthritis (CIA) DBA/1J mouse model. RAW 264.7 macrophage and DBA/1J mice. Lipopolysaccharide and collagen. RAW 264.7 macrophages stimulated by lipopolysaccharide (LPS) followed by quetiapine