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344085

Sigma-Aldrich

Folimycin, Streptomyces sp.

A highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM).

Synonym(s):

Folimycin, Streptomyces sp., Concanamycin A

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About This Item

Empirical Formula (Hill Notation):
C46H75NO14
CAS Number:
80890-47-7
Molecular Weight:
866.09
MDL number:
MFCD00210037
UNSPSC Code:
12352200

Quality Level

100

Assay

≥90% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

solubility

DMSO: soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2,1-12H3,(H2,47,53)/b16-13+,18-15+,24-17+,25-20+,36-21-/t26-,27-,28-,29+,30+,31-,32+,33-,34-,35+,37-,38+,39+,40-,41-,42-,43-,46-/m1/s1

InChI key

DJZCTUVALDDONK-HQMSUKCRSA-N

General description

A highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM). Inhibits acidification of organelles, such as lysosomes and the Golgi apparatus. Also blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. Useful for studies of intracellular protein translocation. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Vacuolar-type H+-ATPase
Product does not compete with ATP.
Reversible: no
Target Ki: 20 pM against vacuolar-type H+-ATPase

Warning

Toxicity: Highly Toxic (H)

Preparation Note

Further dilute with aqueous buffers just prior to use.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Kane, M.D., et al. 1999. J. Neurochem.72, 1939.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun.212, 255.
Muroi, M., et al. 1994. Biosci. Biotech. Biochem.58, 425.
Drose, S., et al. 1993. Biochemistry32, 3902.
Muroi, M., et al. 1993. Biochem. Biophys. Res. Commun.193, 999.
Muroi, M., et al. 1993. Cell Struct. Funct.18, 139.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300 + H310 + H330,H319

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Synapse formation is achieved by various synaptic organizers. Although this process is highly regulated by neuronal activity, the underlying molecular mechanisms remain largely unclear. Here we show that Cbln1, a synaptic organizer of the C1q family, is released from lysosomes

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