Skip to Content
Merck

CTCF

CCCTC-binding factor (zinc finger protein)

Synonyms:
Species:
Human CTCF (10664), Mouse Ctcf (13018), Rat Ctcf (83726), domestic guinea pig Ctcf (100732580), Domestic Rabbit CTCF (100350641), chicken CTCF (396274), naked mole-rat Ctcf (101709585), Zebrafish ctcf (415104), domestic cat CTCF (101101354), sheep CTCF (101114297) ...More
UniProtKB ID:
P49711, B5MC38, Q53XI7, Q59EL8
Gene ID:
  • Human(10664) Summary: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(13018) CCCTC-binding factor
  • Rat(83726) CCCTC-binding factor (zinc finger protein)
  • domestic guinea pig(100732580) CCCTC-binding factor (zinc finger protein)
  • Domestic Rabbit(100350641) CCCTC-binding factor (zinc finger protein)
  • chicken(396274) CCCTC-binding factor (zinc finger protein)
  • naked mole-rat(101709585) CCCTC-binding factor (zinc finger protein)
  • Zebrafish(415104) CCCTC-binding factor (zinc finger protein)
  • domestic cat(101101354) CCCTC-binding factor (zinc finger protein)
  • sheep(101114297) CCCTC-binding factor (zinc finger protein)
  • cow(517097) CCCTC-binding factor (zinc finger protein)
  • Horse(100053363) CCCTC-binding factor (zinc finger protein)
  • dog(479684) CCCTC-binding factor (zinc finger protein)
  • fruit fly(38817) CG8591 gene product from transcript CG8591-RA

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
07-729
Anti-CTCF Antibody, serum, Upstate®,
Species Reactivity
canine, human, mouse, primate, rat
Application
ChIP
western blot
SAB5701051
Anti-CTCF antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
SAB5701285
Anti- CTCF antibody produced in rabbit, ,
Species Reactivity
human
Application
immunohistochemistry
western blot
SAB5701132
Anti- CTCF antibody produced in rabbit, ,
Species Reactivity
all
Application
immunohistochemistry
western blot
HPA004122
Anti-CTCF antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

esiRNA

Product Number
Description
Species
EMU044061
MISSION® esiRNA, targeting mouse Ctcf,
Species
mouse
EHU130111
MISSION® esiRNA, targeting human CTCF,
Species
human