Skip to Content
Merck

CDK8

cyclin-dependent kinase 8

Synonyms:
K35
Species:
UniProtKB ID:
Gene ID:
  • Human(1024) Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008]
  • Mouse(264064) cyclin-dependent kinase 8
  • domestic guinea pig(100718250) cyclin-dependent kinase 8
  • naked mole-rat(101719987) cyclin-dependent kinase 8
  • sheep(101115551) cyclin-dependent kinase 8
  • Domestic Rabbit(100353845) cyclin-dependent kinase 8
  • domestic cat(101086278) cyclin-dependent kinase 8
  • Zebrafish(373868) cyclin-dependent kinase 8
  • cow(507149) cyclin-dependent kinase 8
  • dog(486035) cyclin-dependent kinase 8
  • chicken(428080) cyclin-dependent kinase 8
  • Horse(100050819) cyclin-dependent kinase 8
  • fruit fly(39157) Cyclin-dependent kinase 8

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CDK8 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, horse, human, mouse, pig, rabbit
Application
western blot
Anti-CDK8 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
western blot
ANTI-CDK8 antibody produced in mouse, clone 5H4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-CDK8, affinity isolated antibody,
Species Reactivity
human, mouse
Application
immunohistochemistry
Anti-CDK8 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Olomoucine, ≥98% (HPLC),
Species
human, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Cdk8,
Species
mouse
MISSION® esiRNA, targeting human CDK8,
Species
human