BACE1
beta-site APP-cleaving enzyme 1
Synonyms:
ASP2, BACE, HSPC104
Species:
Human BACE1 (23621), Mouse Bace1 (23821), Rat Bace1 (29392), Horse BACE1 (100071137), naked mole-rat Bace1 (101701890), sheep BACE1 (101119667), dog BACE1 (489390), cow BACE1 (614333), chicken BACE1 (419768), Zebrafish bace1 (403005) ...More
UniProtKB ID:
Gene ID:
- Human(23621) Summary: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
- Mouse(23821) beta-site APP cleaving enzyme 1
- Rat(29392) beta-site APP cleaving enzyme 1
- Horse(100071137) beta-site APP-cleaving enzyme 1
- naked mole-rat(101701890) beta-site APP-cleaving enzyme 1
- sheep(101119667) beta-site APP-cleaving enzyme 1
- dog(489390) beta-site APP-cleaving enzyme 1
- cow(614333) beta-site APP-cleaving enzyme 1
- chicken(419768) beta-site APP-cleaving enzyme 1
- Zebrafish(403005) beta-site APP-cleaving enzyme 1
- domestic cat(101086840) beta-site APP-cleaving enzyme 1
- domestic guinea pig(100135485) beta-site APP cleaving enzyme 1
- Domestic Rabbit(100343442) beta-site APP-cleaving enzyme 1
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ELISA
Product Number
Description
Species
Activity Assay
Product Number
Description
Species
β-Secretase (BACE1) Activity Detection Kit (Fluorescent), 1 kit sufficient for 250 reactions,
Species
human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-BACE Antibody, CT, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-BACE Antibody, CT, clone 61-3E7, clone 61-3E7, Chemicon®, from mouse,
Species Reactivity
human, mouse, primate, rat
Application
immunoprecipitation (IP)
western blot
western blot
Anti-BACE antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
Anti-BACE1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-BACE 1, N-Terminus (46-62) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Small Molecule - Inhibitor
Kits
Product Number
Description
Species
β-Secretase (BACE1) Activity Detection Kit (Fluorescent), 1 kit sufficient for 250 reactions,
Species
human
Proteins
Product Number
Description
Species
β-Secretase human, recombinant, expressed in HEK 293 cells (C-terminal FLAG tagged), extracellular domain, ≥10,000 units/mg protein, ≥90% (SDS-PAGE), buffered aqueous solution,
Species
human