Evaluation of cytochrome P-450 mediated metabolism of antipyrine in the rat at different extents of fluosol-DA hemodilution.

Two reports of antipyrine disposition in rats after hemodilution with 20, 40, or 80 ml/kg of Fluosol-DA are evaluated to determine if the extent of hemodilution influenced cytochrome P-450 mediated antipyrine metabolism. Alterations in antipyrine clearance (Cl) and 3-hydroxymethylantipyrine (3OHME) formation clearance (ClF) show that the extent of Fluosol hemodilution influences both the time and pattern of change in cytochrome P-450 isoenzyme activity. Alterations in antipyrine Vd had no consistent pattern with different extents of hemodilution.