Direkt zum Inhalt
Merck

V2876

Vitamin B12

≥98%

Synonym(e):

α-(5,6-Dimethylbenzimidazolyl)cyanocobamid, CN-Cbl, Cyanocob(III)alamin, Cyanocobalamin

Anmelden zur Ansicht der Organisations- und Vertragspreise.

Größe auswählen

100 MG

€ 60,10

250 MG

€ 72,50

500 MG

€ 142,00

1 G

€ 199,00

5 G

€ 655,00

25 G

€ 2.580,00

€ 60,10


Ab HEUTE lieferbarDetails


Großbestellung anfragen

Über diesen Artikel

Empirische Formel (Hill-System):
C63H88CoN14O14P
CAS-Nummer:
Molekulargewicht:
1355.37
PubChem Substance ID:
eCl@ss:
34058004
UNSPSC Code:
12352205
NACRES:
NA.79
EC Number:
200-680-0
Beilstein/REAXYS Number:
4122889

Fortfahren mit

Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhalten

assay

≥98%

form

powder

technique(s)

HPLC: suitable

color

red to brown

storage temp.

2-8°C

SMILES string

C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@

InChI

1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1

InChI key

RMRCNWBMXRMIRW-QJRSUKKJSA-L

Suchen Sie nach ähnlichen Produkten? Aufrufen Leitfaden zum Produktvergleich

Ähnliche Artikel vergleichen

Vollständigen Vergleich anzeigen

Unterschiede anzeigen

1 of 4

Dieser Artikel
5.249501.2459247869
Vitamin B12 ≥98%

V2876

Vitamin B12

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

assay

≥98%

assay

-

assay

-

assay

-

form

powder

form

solid

form

solid

form

-

storage temp.

2-8°C

storage temp.

15-25°C

storage temp.

15-25°C

storage temp.

2-8°C

Quality Level

200

Quality Level

500

Quality Level

100

Quality Level

100

color

red to brown

color

-

color

-

color

-

Application

Vitamin B12 wird verwendet:
  • als Bestandteil in Vitaminmischlösungen in der In-vitro-Darmsimulation
  • als Standard in der Massenspektrometrie mit induktiv gekoppeltem Plasma und Größenausschluss (SEC-ICP-MS)
  • als Bestandteil von simulierten Plasmaprotein-Mischungen für die Raman-Spektralanalyse
  • in der Oberflächenplasmonenresonanzanalyse (SPR-Analyse)
  • als Mediumzusatz in ventrikulären Myozyten neugeborener Ratten (NRVM)

Biochem/physiol Actions

Vitamin B12 (Cobalamin) bezieht sich auf eine Gruppe chemisch-verwandter kobalthaltiger Moleküle, die an Zellprozessen wie der DNA-Synthese, Fettsäuresynthese, Energieproduktion und -regulation beteiligt sind. Die physiologisch aktiven Formen von Vitamin B12 umfassen Methylcobalamin und Adenosylcobalamin, während Hydroxocobalamin (Vitamin B12a, OHCbl) und Cyanocobalamin (CNCbl) Speicher- und Darreichungsformen sind. Von Bakterien produziertes Hydroxocobalamin (OHCbl) und CNCbl werden beim Menschen in nützliche Coenzymformen umgewandelt, um Stoffwechselprozesse wie die mitochondriale Methylmalonyl-Coenzym-A-Mutase-Umwandlung von Methylmalonsäure (MMA) in Succinat zur Verknüpfung des Lipid- und Kohlenhydratstoffwechsels sowie die Aktivierung der Methioninsynthase, den limitierenden Faktor in der Synthese von Methionin, zu unterstützen.

Lagerklasse

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

Die passende Version wird nicht angezeigt?

Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Recombinant human collagen-based microspheres mitigate cardiac conduction slowing induced by adipose tissue-derived stromal cells
Smit NW, et al.
PLoS ONE, 12(8), e0183481-e0183481 (2017)
Raman spectroscopic analysis of high molecular weight proteins in solution-considerations for sample analysis and data pre-processing
Parachalil DR, et al.
Analyst, 143(24), 5987-5998 (2018)
Speciation of zinc in fish feed by size exclusion chromatography coupled to inductively coupled plasma mass spectrometry-Using fractional factorial design for method optimization and mild extraction conditions
Silva MS, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1104, 262-268 (2018)
Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
Koh A, et al.
Cell, 175(4), 947-961 (2018)
A missense mutation in TCN2 is associated with decreased risk for congenital heart defects and may increase cellular uptake of vitamin B12 via Megalin
Li P, et al.
Oncotarget, 8(33), 55216-55216 (2017)

Global Trade Item Number

SKUGTIN
V2876-500MG04061835514359
V2876-100MG04061835550494
V2876-1G04061835550500
V2876-25G04061837480799
V2876-5G04061835550517
V2876-250MG04061835514342

Questions

1–9 of 9 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. how long we can store aqueous solution of Vitamin B12 (2876)?

    1 answer
    1. The stability of this product in aqueous solution has not been investigated. It would be up to the end user to determine solution storage and stability. As a conservative measure, it would be recommended to prepare solutions fresh, as needed. However, sterile solutions for injection are available for theratpeutic use and appear to be stable at ambient temperature. These solutions tend to have a pH range from neutral to acidic and are stored in amber bottles. See the link below to review more information on the therapeutic versions of Vitamin B12/Cyanocolamain for injection. https://www.drugs.com/pro/b-2-inject-kit.html

      Helpful?

  4. Is it possible to use ethanol to make a solution of Vitamin B12, Product V2876? May i know the right concentration?

    1 answer
    1. This product is soluble in 50 mg/ml of H2O as stated on the Certificate of Analysis. The solubility of the product in ethanol has not been tested.

      Helpful?

  5. What is the Extinction Coefficient for Vitamin B12, Product V2876?

    1 answer
    1. Extinction Coefficient: E1% = 64 (550 nm), 204 (361 nm), 115 (278 nm) in water.  Extinction Coefficient: EmM = 27.5 (361 nm) in water.

      Helpful?

  6. How should I store a solution of Vitamin B12, Product V2876?

    1 answer
    1. Serum Vitamin B12 is highly unstable and should be protected from light and kept frozen. Cyanocobalamin is often used to supplement media. It has a maximal stability at pH = 7, but is photolysed to hydroxocobalamin with a zero-order rate constant.

      Helpful?

  7. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  8. What can I use to make a solution of Vitamin B12, Product V2876?

    1 answer
    1. The specification sheet for Product V2876 (available from the product page on the website) indicates that the product is soluble in water (50 mg/mL), yielding a dark red solution.

      Helpful?

  9. Vitamin B12, Product V2876, is produced by fermentation.  What bacteria is used to produce this product?

    1 answer
    1. The bacterial source for this product is considered proprietary.

      Helpful?

Reviews

No rating value

Active Filters

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung