T8325

TDZD-8

≥98% (HPLC), needles

• Synonym(e): 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
• Empirische Formel (Hill-System): C₁₀H₁₀N₂O₂S
• CAS-Nummer: 327036-89-5
• Molekulargewicht: 222.26
• NACRES: NA.77
• PubChem Substance ID: 329826879
• UNSPSC Code: 12352200
• MDL number: MFCD04973552
• Assay: ≥98% (HPLC)
• Form: needles
• Storage condition: protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: needles
• storage condition: protect from light
• color: white
• mp: 63-64.4 °C
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: CN1SC(=O)N(Cc2ccccc2)C1=O
• InChI: 1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
• InChI key: JDSJDASOXWCHPN-UHFFFAOYSA-N

Beschreibung

Application

TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program[1]. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb[2].

Biochem/physiol Actions

TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.

TDZD-8 is a selective inhibitor of GSK-3.

Features and Benefits

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves