T4512

(±)-Taxifolin hydrate

≥90% (HPLC)

• Synonym(s): 3,3′,4′,5,7-Pentahydroxyflavanone hydrate, Dihydroquercetin hydrate
• Empirical Formula (Hill Notation): C₁₅H₁₂O₇ · xH₂O
• CAS Number: 24198-97-8
• Molecular Weight: 304.25 (anhydrous basis)
• NACRES: NA.25
• PubChem Substance ID: 24278739
• UNSPSC Code: 12352200
• MDL number: MFCD11044454

Properties

• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: powder
• solubility: DMSO: 20 mg/mL
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• SMILES string: O.O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c3ccc(O)c(O)c3
• InChI: 1S/C15H12O7.H2O/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6;/h1-5,14-19,21H;1H2/t14-,15+;/m0./s1
• InChI key: DNQPGSVMBPSRIR-LDXVYITESA-N
• Gene Information: mouse ... Hexa(15211)

Description

General description

Taxifolin or dihydroquercetin is a naturally occurring secondary metabolic compound[1] found in many plants such as onions, milk thistle, Douglas fir bark, and French maritime pine bark.[2]

Application

(±)-Taxifolin hydrate has been used to evaluate its effects when co-supplemented with trehalose to improve the quality of post-thawed ram semen.[3] It may have been used as a reference standard to analyze the bioactive components of ethanolic extract of P. orientale (POE) using high-performance liquid chromatography (HPLC).[4]

Biochem/physiol Actions

(±)-Taxifolin exerts various pharmacological properties that include anti-inflammatory, anti-cancer, antiviral,[1] and antimicrobial activities.[2] It displays neuroprotective, hepatoprotective effects, and it also protects against cardiovascular diseases.[2]

Flavonoid, antioxidant. Inhibits lipogenesis in cancer cells, most likely by targeting fatty acid synthase activity.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves