SRP2067

CAR, ligand binding domain (101-348) human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

• Synonym(e): CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
• UNSPSC-Code: 12352202
• NACRES: NA.26

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in E. coli
• Assay: ≥85% (SDS-PAGE)
• Form: frozen liquid
• Mol-Gew.: ~30 kDa
• Verpackung: pkg of 10 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Konzentration: 500 μg/mL
• Farbe: clear; colorless
• NCBI-Hinterlegungsnummer: NM_005122
• UniProt-Hinterlegungsnummer: Q14994
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... NR1I3(9970)

Beschreibung

Biochem./physiol. Wirkung

The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively active, it can be further activated by `phenobarbitol-like` compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.

Physikalische Form

Clear and colorless frozen liquid solution

Angaben zur Herstellung

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable