SML3537

CK156

≥98% (HPLC)

• Synonym(e): N-tert-Butyl-7,10-dioxa-13,17,18,21-tetraazatetracyclo[12.5.2.1²,⁶.0¹⁷,²⁰]docosa-1(20),2,4,6(22),14(21),15,18-heptaene-5-carboxamide
• Empirische Formel (Hill-System): C₂₁H₂₅N₅O₃
• Molekulargewicht: 395.45
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: CC(C)(C)NC(C(C=C1)=C(OCCOCCNC2=N3)C=C1C4=C3N(C=C2)N=C4)=O

Beschreibung

Biochem./physiol. Wirkung

CK156 is a potent and selective DRAK1 inhibitor (IC50 = 49 nM by cell-free radiometric assay, IC50 = 181 nM by cellular NanoBRET, KD = 21 nM by ITC, selectivity by a 468-kinase panel) with good selectivity over DRAK2 (61% inhibition at 1 μM, IC50 = 8 μM by NanoBRET).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable